Review scope

This summary is based on the published abstract. We have not appraised the full methods, tables or supplementary material. Details absent from the abstract remain unverified.

Question and design

26 dogs with naturally occurring chronic small-intestinal disease: 18 test and eight control. Hydrolysed-protein food, assessed at approximately three months, 6–12 months and three years. Comparator: A highly digestible control food.

What was measured?

Symptoms, clinical activity, body weight and other treatment requirements.

Main findings

Initial response did not differ significantly. More test-diet dogs remained symptom-free at later assessments, with a greater reduction in clinical activity scores.

Study strengths

Random allocation, clinical patients and longer-term follow-up.

Limitations

Open-label, small unequal groups; baseline clinical severity was higher in the test group. Attrition and full methods were not appraised.

Researchers’ conclusion

The authors supported the diet for long-term management of this clinical population.

Evidence.pet interpretation

This supports a veterinary dietary option, not a general claim that hydrolysed ingredients cure digestive disease.

Funding and conflicts

Not verified from the abstract; full declarations have not been reviewed.

Source and review date

Mandigers PJJ et al. A randomized, open-label, positively-controlled field trial of a hydrolyzed protein diet in dogs with chronic small bowel enteropathy. Journal of Veterinary Internal Medicine. 2010;24(6):1350–1357.

Read the primary source · DOI record

STU-034. Reviewed 25 September 2026. Next review 25 December 2026.